Zhrnutie
About the Role
Preferred start date / 1st of July 2024 onwards
Duration: Initial contract up to two years
Your responsibilities:
- Provide support to the development of therapeutic protein characterization methods by liquid chromatography coupled to mass spectrometry (LC-MS) based workflows
- Implementation of (semi-) quantitative methods for the monitoring and reporting of targeted product quality attributes as well as new peaks of therapeutic proteins using state-of-the-art LC-MS equipment and software, by e.g. multi-attribute method (MAM) or targeted LC-MS assay
- Plan and perform automated protein enzymatic digestion on a robotic system
- Perform project-specific method qualification and assessment of method robustness, where applicable
- Documentation of experiments and results in electronic systems
What you’ll bring to the role:
- Education: MSc in Biotechnology, Biochemistry, Analytical Chemistry or related field. Relevant work experience would be an asset.
- Languages: Strong communication skills in English; proficiency in German or French would be an asset
- Experience/Professional requirements:
- Strong hands-on experience in liquid chromatography (HPLC and UHPLC e.g. Vanquish™)
- Hands-on experience in protein sample preparation and analysis (e.g. peptide mapping by LC-MS) preferably using automated sample preparation on a robotic system (e.g. Hamilton STARlet)
- Strong theoretical knowledge of protein biochemistry and protein posttranslational modifications
- Theoretical knowledge and previous experience working with mass spectrometers (e.g. Orbitrap and Q-ToF analyzers)
- Experience desired with selected reaction monitoring (SRM), parallel reaction monitoring (PRM), selected ion monitoring (SIM), or new peak detection (NPD)
- Experience with Chromeleon and/or Genedata Expressionist would be an asset
Please submit a cover letter that includes your motivation for the position and from when you will be available. Thank you.
Commitment to Diversity and Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
Accessibility and accommodation:
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to diversity.inclusion_ch@novartis.com, and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
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